【早老SAM-P8小鼠现货购买快速老化SAMp8小鼠价格低】价格

库存：SAMP8小鼠各月龄数量多

英文名：SAMP8小鼠SAM-p8快速早老小鼠

CAS号：20200228

保质期：SAMP8小鼠SAM-p8快速早老小鼠

供应商：SAMP8小鼠SAM-p8快速早老小鼠

保存条件：24摄氏度

规格：SAMP8小鼠价格请咨询

Samp8小鼠动物毛色：	白色
Samp8小鼠对照背景小鼠	Samr1
Samp8小鼠供应月龄	1-8m

SAMP8小鼠SAM-p8快速早老小鼠部分使用单位：广东药科大学、天津中医药大学、江南大学、华南师范大学、宁夏医科大学、中国中医科学院、同济医院、中科院遗传与发育研究所、北京师范大学、国家体育总局体育科学研究所、河北医科大学，中国医科大学、山东大学、齐鲁医院、复旦大学、瑞金医院、中科院上海药物研究所、上海交通大学、第二军医大学、第四军医大学、中科院生物物理所、南方医科大学、武汉协和、中国医学科学院等均使用本单位提供SAMP8小鼠SAM-p8快速早老小鼠动物进行研究
本企业2000年成立，专业提供SPF级SAMP8小鼠samp8mice快速老化小鼠销售价格优惠，SPF级SAMR1小鼠samp8mice快速老化小鼠销售价格优惠，保质保量，提供质量合格证，可送货到实验室

STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs