GEP100/IQSEC1 ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

目录编号 ：LM-13960R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：GEP100/IQSEC1

抗体名 ：ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, 

免疫原 ：KLH conjugated synthetic peptide derived from human GEP100:451-550/963 

亚型 ：IgG

形态 ：Lyophilized or Liquid

应用范围 ：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

浓度 ：1mg/ml

保存条件 ：Store at -20 °C

规格 ：100ul  200ul

GEP100/IQSEC1 ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体

英文名称	GEP100/IQSEC1
中文名称	ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体
别    名	ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF GEP100; ARFGEP100; BRAG2; Brefeldin A resistant ARF GEF2; Brefeldin-resistant Arf-GEF 2 protein; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; IQEC1_HUMAN; Iqsec1; Kiaa0763.
规格价格	100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书	100ul  200ul
研究领域	肿瘤  细胞生物  信号转导  转录调节因子  G蛋白信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	108kDa
细胞定位	细胞核 细胞浆
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human GEP100:451-550/963
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells. Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. Subcellular Location: Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic. Tissue Specificity: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. Similarity: Belongs to the BRAG family. Contains 1 IQ domain. Contains 1 PH domain. Contains 1 SEC7 domain. SWISS: Q6DN90 Gene ID: 9922 Database links: Entrez Gene: 9922 Human Omim: 610166 Human SwissProt: Q6DN90 Human Unigene: 475506 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.