phospho-APC1 (Ser377) antibody

供应商 ：上海康朗生物科技有限公司

库存 ：大量

目录编号 ：kl-5174R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：12个月

抗体英文名 ：phospho-APC1 (Ser377) antibody

抗体名 ：磷酸化细胞周期末期促进复合蛋白APC1抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

免疫原 ：KLH conjugated Synthesised phosphopeptide derived from human ANAPC1 around the phosphorylation site of Ser377:NQ(p-S)PK

亚型 ：IgG

形态 ：冻干粉或液体

应用范围 ：ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul

phospho-APC1 (Ser377) antibody

中文名称	磷酸化细胞周期末期促进复合蛋白APC1抗体
别    名	Apc1 (phospho S377); p-Apc1 (phospho S377); phospho-ANAPC1(Ser377); ANAPC 1; ANAPC1; Anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); Anaphase-promoting complex subunit 1; Apc 1; APC1; APC1_HUMAN; Cyclosome subunit 1; MCPR; Meiotic checkpoint regulator; Mitotic checkpoint regulator; Protein Tsg 24; Protein Tsg24; Testis-specific gene 24 protein; TSG 24; TSG24.
规格价格	100ul/1580元 购买        大包装/询价
说 明 书	100ul
产品类型	磷酸化抗体
研究领域	细胞生物  免疫学  细胞周期蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	212kDa
细胞定位	细胞核 细胞浆
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated Synthesised phosphopeptide derived from human ANAPC1 around the phosphorylation site of Ser377:NQ(p-S)PK
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]. Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  Subunit: The APC/C is composed of at least 12 subunits.  Post-translational modifications: Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis. Similarity: Belongs to the APC1 family. Contains 4 PC repeats.  SWISS: Q9H1A4 Gene ID: 64682 Database links: Entrez Gene: 64682 Human Entrez Gene: 535565 Cow Entrez Gene: 475750 Dog Entrez Gene: 17222 Mouse Omim: 608473 Human SwissProt: E1BAB6 Cow SwissProt: E2RLM2 Dog SwissProt: Q9H1A4 Human   Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-APC1 (Ser377)) Polyclonal Antibody, Unconjugated (bs-5174R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.