TGF beta Receptor I转移生长因子β受体1抗体

供应商 ：上海联迈生物工程有限公司

库存 ：大量

目录编号 ：LM-0638R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：1年

抗体英文名 ：TGF beta Receptor I

抗体名 ：转移生长因子β受体1抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Cow, 

免疫原 ：KLH conjugated synthetic peptide derived from human TGF-beta R1:301-400/501 <Extracellular>

亚型 ：IgG

形态 ：Lyophilized or Liquid

应用范围 ：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

浓度 ：1mg/ml

保存条件 ：Store at -20 °C

规格 ：50ul  100ul  200ul

TGF beta Receptor I转移生长因子β受体1抗体

英文名称	TGF beta Receptor I
中文名称	转移生长因子β受体1抗体
别    名	TGFBR1; TGF Beta R1; TGF beta Receptor I; AAT 5; AAT5; Activin A receptor type II like kinase 53kDa; Activin receptor like kinase 5; ACVRLK 4; ACVRLK4; ALK 5; ALK5; Serine/threonine protein kinase receptor R4; SKR 4; SKR4; TbetaR I; TGF beta receptor type 1; TGF beta receptor type I; TGF beta type I receptor; TGFBR 1; TGFBR1 protein; TGFR 1; TGFR1; Transforming growth factor beta receptor I;   TGF-βRⅠ; TGFβRⅠ; TGF-βR Ⅰ; TGF-β RⅠ.
	Specific References  (3)     |     bs-0638R has been referenced in 3 publications. [IF=3.37] Xie, Weihan, et al. "Regulation of cellular behaviors of fibroblasts related to wound healing by sol‐gel derived bioactive glass particles." Journal of Biomedical Materials Research Part A (2016).  WB ;  Human.   PubMed:27177533 [IF=1.37] Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9.  IHC-P ;  Mouse.   PubMed:24740393 [IF=1.21] Tang, K., et al. "GDF9 affects the development and tight junction functions of immature bovine Sertoli cells." Reproduction in Domestic Animals (2017).  WB ;  Bovine.   PubMed:28332739
规格价格	50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书	50ul  100ul  200ul
研究领域	肿瘤  神经生物学  信号转导  生长因子和激素  细胞膜受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Cow,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	55kDa
细胞定位	细胞膜
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human TGF-beta R1:301-400/501 <Extracellular>
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. Subunit: Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Tissue Specificity: Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Post-translational modifications: Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. SWISS: P36897 Gene ID: 7046 Database links: Entrez Gene: 7046 Human Entrez Gene: 21812 Mouse Entrez Gene: 29591 Rat Entrez Gene: 282382 Cow Omim: 190181 Human SwissProt: O46680 Cow SwissProt: P36897 Human SwissProt: Q64729 Mouse SwissProt: P80204 Rat Unigene: 494622 Human Unigene: 197552 Mouse Unigene: 44402 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  细胞膜受体（Membrane Receptors)TGF-βRⅠ
产品图片	Sample:  293T(Human) Cell Lysate at 40 ug A431(Human) Cell Lysate at 40 ug Primary: Anti-TGF beta Receptor I (bs-10196R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD Sample: Small intestine (Mouse) Lysate at 30 ug Primary: Anti- TGF beta Receptor 1 (bs-0638) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD Sample:  Lane1: Gastric carcinoma(Human) Lysate at 30 ug Lane2:Stomach (Mouse) Lysate at 30 ug Primary: Anti-TGF Beta R1/TGFBR1 (bs-0638R) at 1:200 dilution;  Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution;  Predicted band size : 55kD Observed band size : 55kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min;  Incubation: Anti-TGF Beta R1/TGFBR1 Polyclonal Antibody, Unconjugated(bs-0638R) 1:200, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Paraformaldehyde-fixed, paraffin embedded (Rat small intestine); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation: Anti-TGF beta Receptor I Antibody, conjugated (bs-0638R-AF594) at 1:100 overnight at 4°C; DAPI (5ug/ml, blue, C-0033) was used to stain the cell nuclei.