CYFIP2 antibody

供应商 ：上海康朗生物科技有限公司

库存 ：大量

目录编号 ：kl-14140R

克隆性 ：多克隆

抗原来源 ：Rabbit

保质期 ：12个月

抗体英文名 ：CYFIP2 antibody

抗体名 ：细胞质FMR1相关蛋白2抗体

宿主 ：Rabbit

适应物种 ：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,

免疫原 ：KLH conjugated synthetic peptide derived from human CYFIP2:251-350/1278

亚型 ：IgG

形态 ：冻干粉或液体

应用范围 ：ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500

浓度 ：1mg/ml

保存条件 ：-20 °C

规格 ：100ul 200ul

CYFIP2 antibody

中文名称	细胞质FMR1相关蛋白2抗体
别    名	CYFP2; cytoplasmic FMR1 interacting protein 2; KIAA1168; p53 inducible protein; p53-inducible protein 121; PIR121; CYFP2_HUMAN.
规格价格	100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书	100ul  200ul
研究领域	细胞生物  发育生物学  神经生物学  信号转导  t-淋巴细胞
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
产品应用	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量	146kDa
细胞定位	细胞核 细胞浆
性    状	Lyophilized or Liquid
浓    度	1mg/ml
免 疫 原	KLH conjugated synthetic peptide derived from human CYFIP2:251-350/1278
亚    型	IgG
纯化方法	affinity purified by Protein A
储 存 液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: CYFIP2 is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. Function: CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing. Subcellular Location: Cytoplasm perinuclear region. Cell junction, synapse, synaptosome. Treatment with leptomycin-B triggers translocation to the nucleus. Similarity: Belongs to the CYFIP family. SWISS: Q96F07 Gene ID: 26999 Database links: Entrez Gene: 26999 Human Entrez Gene: 76884 Mouse Entrez Gene: 303073 Rat Omim: 606323 Human SwissProt: Q96F07 Human SwissProt: Q5SQX6 Mouse Unigene: 910449 Human Unigene: 293961 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CYFIP2) Polyclonal Antibody, Unconjugated (bs-14140R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.