临床前全面心脏安全评价服务

服务名称 ：临床前全面心脏安全评价服务

• Cellular level - manual patch-clamp (IC50 value, 22°C)
  • hERG ( IKr )
  • Nav1.5
  • Kv1.5
  • Nav1.7
  • All currents on cardiac myocytes from rat, mouse, rabbit and guinea pig
• Tissue level (cardiac tissue at 37°C)
  • Intracellular microelectrode action potential recordings
  • Sinus node (rabbit), Purkinje fiber (dog, rabbit), papillary muscle (guinea pig)
  • Ventricular and atrial tissue preparations from rabbit, guinea pig and rat
• Organ and whole animal level
  • Langendorff isolated heart preparations
  • Telemetry-implanted guinea pig and dog
  • Isolate heart AF disease model
  • Reperfusion ischemia model