Recombinant Murine Noggin

库存 ：大量

英文名 ：Recombinant Murine Noggin

保质期 ：一年

供应商 ：上海联迈生物工程有限公司

保存条件 ：-20℃或更低温度保存

规格 ：1mg

Recombinant Murine Noggin

产品编号	产品名称	产品包装	产品价格
LM6191-1mg	Recombinant Murine Noggin	1mg	20076.00元

 

Species	Gene ID	Accession	Source	Length	MW	Tag
Mouse	18121	LM97466	E. coli	206aa	46.4kDa	－

 

About this Antibody
Name	Recombinant Murine Noggin (Recombinant Murine Noggin; rMuNoggin)；Recombinant Mouse Noggin ; 重组小鼠生长因子
Synonyms	NOG; SYM1; SYNS1; noggin; SYM1; symphalangism 1 (proximal); synostoses (multiple) syndrome 1; SYNS1
Purity	>95% by SDS-PAGE and HPLC analyses.
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4-induced alkaline phosphatase production of murine ATDC5 cells is less than 2ng/ml, corresponding to a specific activity of >5.0×105IU/mg in the presence of 5ng/ml BMP-4.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	Lyophilized from a 0.2μM filtered concentrated solution in 30% acetonitrile, 0.1% TFA.
Endotoxin	Less than 1EU/μg of rMuNoggin as determined by LAL method.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration less than 0.25mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
Category	Cytokine
Background	Noggin encoded by the NOG gene, was first isolated from Xenopus, having the function of inducing secondary axis formation in frog embryos. It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin was originally found as a BMP-4 antagonist, and then has been shown to modulate the activities of other BMPs (BMP-2, 7, 13 and 14). Additionally, it has pleiotropic effect, both in early development and later stages. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. In recent report, proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have relation with the mutant of evolutionarily conserved amino acid residues of Noggin. Mature mouse Noggin shares 99% and 83%a.a. sequence identity with human and Xenopus Noggin, respectively.
Amino Acid Sequence	MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC

包装清单:

产品编号	产品名称	包装
LM6191-5μg	Recombinant Murine Noggin	5μg
LM6191-20μg	Recombinant Murine Noggin	20μg
LM6191-100μg	Recombinant Murine Noggin	100μg
LM6191-1mg	Recombinant Murine Noggin	1mg
-	说明书	1份

保存条件:
       -20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
       由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
       本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
       为了您的安全和健康，请穿实验服并戴一次性手套操作。