嗜酸性粒细胞颗粒关键碱性蛋白抗体图片

嗜酸性粒细胞颗粒关键碱性蛋白抗体图片

价格: 询价

品牌:上海一研

货号:EY-11176

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抗体名 :嗜酸性粒细胞颗粒关键碱性蛋白抗体

抗体英文名 :Anti-PRG2

靶点 :详见说明书

浓度 :1mg/1ml

应用范围 :WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

宿主 :详见说明书

供应商 :上海一研

库存 :21

级别 :详见说明书

目录编号 :详见说明书

抗原来源 :Rabbit

保质期 :详见说明书

适应物种 :详见说明书

标记物 :详见说明书

克隆性 :多克隆

保存条件 :Store at -20 °C

形态 :详见说明书

亚型 :IgG

免疫原 : KLH conjugated synthetic peptide derived from human PRG2

规格 :0.2ml/200μg

嗜酸性粒细胞颗粒关键碱性蛋白抗体图片储存温度:
 存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下,抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融,因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏,或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀,就应该存放于室温下的叠氮钠溶液中。
嗜酸性粒细胞颗粒关键碱性蛋白抗体图片按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类。
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英文名称  Anti-PRG2 
中文名称
嗜酸性粒细胞颗粒关键碱性蛋白抗体图片
别    名  BMPG; EMBP; Eosinophil granule major basic protein; Eosinophil major basic protein; MBP; MBP1; Natural killer cell activator; Pregnancy-associated major basic protein; PRG 2; PRG2; PRG2_HUMAN; Proteoglycan 2; Proteoglycan 2 bone marrow; Proteoglycan 2 preproprotein. 
浓    度  1mg/1ml 
规 格  0.2ml/200μg
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse, Rat
产品类型  一抗    
研究领域  细胞生物 免疫学 自然杀伤细胞 淋巴细胞  
蛋白分子量  predicted molecular weight: 25kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human PRG2 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
(石蜡切片需做抗原修复) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
产品介绍 The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Function : Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Subunit : In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
Subcellular Location : Bone marrow proteoglycan: Secreted. Note=The proform is secreted. 
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Tissue Specificity : High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
Post-translational modifications : Nitrated.
Similarity : Contains 1 C-type lectin domain.
Database links : NCBI Reference Sequence: NP_002719.3
UniProtKB/Swiss-Prot: P13727.2 

IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来,聚成一堆便于巨噬细胞的吞噬;
IgG抗体激活补体,中和多种毒素。IgG持续的时间长,是唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳,使新生儿得 到保护;
IgA抗体进入身体的黏 膜表面,包括呼吸、消化、生殖等管道的黏膜,中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中,是在母乳中含量最多,最为重要的一类抗体;
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后,嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体;
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上,可能与B细胞的分化有关。(IgD于1995年从人骨髓瘤蛋白中发现,分子量为175kD,主要由扁桃体、脾等处浆细胞产生,人血清中IgD浓度为3~40μg/ml,不到血清总Ig的1%,在个体发育中合成较晚。IgD铰链区很长,且对蛋白酶水解敏感,因此IgD半衰期很短,仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段,除了表达SmIgD,抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时,SmIgD逐渐消失。
嗜酸性粒细胞颗粒关键碱性蛋白抗体图片的分类:
按作用对象,可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体(能与细胞结合的免疫球蛋白,如1型变态反应中的lgE反应素抗体,能吸附在靶细胞膜上);按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类;按抗体的来源,可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白,是改变了的球蛋白分子。由特异性抗原刺激产生,抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用,使淋巴细胞中的B细胞分化增殖而形成浆细胞,浆细胞可产生分泌抗体。
GoatAnti-humanIgG/Cy3Cy3标记的羊抗人IgG规格:0.1ml
Desmocollin4桥粒糖蛋白4抗体规格:0.2ml
RabbitAnti-pigIgG/AlexaFluor555AlexaFluor555标记的兔抗猪IgG规格:0.1ml
CDCA7L细胞分裂周期相关蛋白JPO2抗体规格:0.2ml
CCDC21卷曲螺旋结构域蛋白21抗体规格:0.2ml
GCS/glucosylceramidesynthase谷氨酸半胱氨酸γ合成酶抗体规格:0.1ml
DPP6二肽基肽酶6抗体规格:0.2ml
GoatAnti-GuineapigIgG羊抗豚鼠IgG规格:1mg
phospho-CFL1/CFL2(Tyr88)磷酸化丝切蛋白抗体规格:0.1ml
Desmoglein1/DSG1桥粒芯糖蛋白1规格:0.1ml
phospho-EphrinB(Tyr329)磷酸化EphrinB抗体规格:0.1ml
RAB35RAS相关蛋白基因Rab35抗体规格:0.2ml
presenilin2/PS-2早老素蛋白-2抗体规格:0.1mlNle13, Glu14] Motilin, human, porcine    Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Nle-Glu-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln
[Trp11]-Neurotensin    Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Trp-Ile-Leu
[Val438]-Tyrosinase (432-444) (human)    Ser-Tyr-Leu-Gln-Asp-Ser-Val-Pro-Asp-Ser-Phe-Gln-Asp

嗜酸性粒细胞颗粒关键碱性蛋白抗体图片Acetalin 1, Opioid Receptor Antagonist 1    Ac-Arg-Phe-Met-Trp-Met-Arg- NH2
Adipophilin    Ser-Val-Ala-Ser-Thr-Ile-Thr-Gly-Val
Amyloid β-Protein (29-40)    Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
AT1A, Angiotensin II receptor, (225-237)    Ala-Tyr-Glu-Ile-Gln-Lys-Asn-Lys-Pro-Arg-Asn-Asp-Asp
Biotin-CRF (human, rat)    Biotin-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
BPDEtide [RKISASEFDRPLR]    Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg
Calcium-Like Peptide    Val-Ala-Ile-Thr-Val-Leu-Val-Lys
Cholecystokinin Octapeptide free acid (desulfated)    Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe
Cys-GM-CSF (17-31)    Cys-Asn-Ala-Ile-Gln-Glu-Ala-Arg-Arg-Leu-Leu-Asn-Leu-Ser-Arg-Asp

 

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