维甲酸受体RAR α/RAR α抗体品牌

抗体名 ：维甲酸受体RAR α/RAR α抗体

抗体英文名 ：Anti-RAR alpha

靶点 ：详见说明书

浓度 ：1mg/1ml

应用范围 ：0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

宿主 ：详见说明书

供应商 ：上海一研

库存 ：59

级别 ：详见说明书

目录编号 ：详见说明书

抗原来源 ：Rabbit

保质期 ：详见说明书

适应物种 ：详见说明书

标记物 ：详见说明书

克隆性 ：多克隆

保存条件 ：Store at -20 °C

形态 ：详见说明书

亚型 ：IgG

免疫原 ： KLH conjugated synthetic peptide derived from human Retinoic acid Receptor Alpha

规格 ：0.2ml/200μg

英文名称  Anti-RAR alpha 
中文名称  维甲酸受体RAR α/RAR α抗体品牌
别    名  Acute Promelocytic Leukemia Breakpoint Cluster Region; Acute Promelocytic Leukemia Breakpoint Cluster Region; NR1B1; Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein; Nuclear receptor subfamily 1 group B member 1; Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form; RAR A; RAR alpha; RAR alpha; RAR alpha form; RAR alpha form; RAR; RAR-alpha; RARA; RARA; RARA protein; RARA/PML Fusion Gene; RARA/PML Fusion Gene; RARA_HUMAN; RARalpha; RARalpha1; Retinoic acid receptor alpha; Retinoic acid receptor alpha polypeptide 
浓    度  1mg/1ml 
规 格  0.1ml/100μg  0.2ml/200μg
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse, Rat
产品类型  一抗    
研究领域  肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶  
蛋白分子量  predicted molecular weight: 48kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human Retinoic acid Receptor Alpha 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 
（石蜡切片需做抗原修复） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
产品介绍 Retinoic acid receptor alpha (RAR-alpha) is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression. Subunit: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.
Function : Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis.
Subunit : Heterodimer; with RXRA. Binds DNA preferentially as a heterodimer. Interacts with CDK7 By similarity. Interacts with coactivators NCOA3 and NCOA6. Interacts with NCOA7; the interaction requires ligand-binding. Interacts with MLL5. Interacts (via the ligand-binding domain) with PRAME; the interaction is ligand (retinoic acid)-dependent. Interacts with AKT1; the interaction phosphorylates RARA and represses transactivation. Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity. Interacts with NCOR1 and NCOR2. Interacts with PRMT2. Interacts with LRIF1. Interacts with ASXL1 and NCOA1.
Subcellular Location : Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Post-translational modifications : Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity. Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosphorylated by PKA in vitro. This phosphorylation on Ser-219 and Ser-369 is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling. 
Sumoylated with SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity. 
Trimethylation enhances heterodimerization with RXRA and positively modulates the transcriptional activation. 
Ubiquitinated.
DISEASE : Chromosomal aberrations involving RARA are commonly found in acute promyelocytic leukemia. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM. The PML-RARA oncoprotein requires both the PML ring structure and coiled-coil domain for both interaction with UBE2I, nuclear microspeckle location and sumoylation. In addition, the coiled-coil domain functions in blocking RA-mediated transactivation and cell differentiation.
Similarity : Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links : Entrez Gene: 5914 Human 
Entrez Gene: 19401 Mouse
Entrez Gene: 24705 Rat
Omim: 180240 Human
SwissProt: P10276 Human
SwissProt: P11416 Mouse
Unigene: 654583 Human
Unigene: 439744 Mouse
类固醇受体（Steroid Receptors） R
维甲酸受体RAR α/RAR α抗体品牌的功能
抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。
公司抗体应用于WB、IHC、IF、ELISA等实验中，维甲酸受体RAR α/RAR α抗体品牌品质保证，提供完善的售前、售中、售后服务！欢迎来电咨询或联系在线客服！我们将竭诚为您服务！
维甲酸受体RAR α/RAR α抗体品牌的优点：
①耐热、耐酸、耐碱、抗有机溶剂以及金属离子，稳定性好，室温下可以长期保存；
②制备简单，操作方便，可以进行批量；
③不必免疫动物，且可获得免疫动物所不能得到的“抗体”；
④可以反复使用；
⑤价格低廉。因此，设计、合成既具有类似生物抗体的高亲合性和高专一性，又具有耐热、耐酸、耐碱且又可以长期稳定的人工抗体，在部分领域替代生物抗体以进行仿生分子识别，或者完成一些生物抗体所不能完成的工作，具有重要的科学意义，在化学、生命科学和环境科学等方面具有广阔的应用前景
公司专业供应各种进口、国产一抗及二抗，品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种，由于产品的数量众多，产品的宿主、抗原来源及应用范围(WB、IH(F/P)、FC、ELISA、IP、IF等)有所不同。
维甲酸受体RAR α/RAR α抗体品牌具有高度的特异性，免疫组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来，以此作为抗原或半抗原，通过免疫动物后获得特异性的抗体，再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的，因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来，以其达到对组织或细胞中的未知抗原进行定性，定位或定量的研究。
维甲酸受体RAR α/RAR α抗体品牌包括以下几个步骤：
1、制备抗原。
2、选择实验动物。
3、动物免疫。
4、试取血进行测试，看看是否成功免疫。
5、如果成功免疫，杀死实验动物，采集全部血清。
6、纯化出抗体。
7、鉴定抗体。包括纯度以及特异性。
abbitAnti-dogIgG/PE-Cy7PE-Cy7标记的兔抗狗IgG规格:0.1ml
RabbitAnti-humanIgG/PEPE标记的兔抗人IgG规格:0.1ml
pan14-3-314-3-3蛋白抗体规格:0.2ml
B7-DC/CD273/PDL2程序性死亡配体2抗体规格:0.1ml
Phospho-Bad(Ser136)磷酸化相关死亡促进因子抗体规格:0.1ml
PSME3/PA28gamma蛋白酶体激活因子PA28γ抗体规格:0.2ml
BRCC4/BRCC45易感基因复合蛋白4抗体规格:0.2ml
GoatAnti-ratIgG/APCAPC标记的羊抗大鼠IgG规格:0.1ml
GoatAnti-GuineapigIgG/Cy5Cy5标记的羊抗豚鼠IgG规格:0.1ml
GoatAnti-rabbitIgG/PE-Cy3PE-Cy3标记的羊抗兔IgG规格:0.1ml
MouseAnti-humanIgM/Cy7Cy7标记的小鼠抗人IgM规格:0.1mlbestatin, human    Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2
Pancreatic Polypeptide (31-36) (human)    Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Phosphorylated Protein Kinase C Substrate 1    Lys-Arg-Pro-pSer-Gln-Arg-His-Gly-Ser-Lys-Tyr-NH2
Prolactin Releasing Peptide (1-31), bovine    Ser-Arg-Ala-His-Gln-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Gly-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
RSK Substrate, S6 (231-239)    Arg-Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala-NH2
维甲酸受体RAR α/RAR α抗体品牌Somatostatin-14 (3-10)    Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr
TIP 39 (39 mer)    Ser-Leu-Ala-Leu-Ala-Asp-Asp-Ala-Ala-Phe-Arg-Glu-Arg-Ala-Arg-Leu-Leu-Ala-Ala-Leu-Glu-Arg-Arg-His-Trp-Leu-Asn-Ser-Tyr-Met-His-Lys-Leu-Leu-Val-Leu-Asp-Ala-Pro
Uru-TK II, Urechistachykinin II    Ala-Ala-Gly-Met-Gly-Phe-Phe-Gly-Ala-Arg-NH2
α-Helical CRF (12-41)    Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2
β-Amyloid (32-35)    Ile-Gly-Leu-Met
[Arg0] Met-Enkephalin    Arg-Tyr-Gly-Gly-Phe-Met
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P    D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2