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英文名 :Borrelia lgM ELISA
供应商 :北京博蕾德生物科技有限公司
Anti-c4d 抗体 (BI-RC4D-PE)背景简介:
C4d是抗体触发补体通过经典途径活化后C4的裂解产物,能稳定地结合在发生排斥的移植物内皮的表面。检测C4d作为机体针对同种异体移植物抗体检测的一个间接信号,大量研究表明:C4d是肾移植免疫中的重要标记物,同时也是心脏、肝及其他器官移植免疫检测的重要标记物。
产品优势:
- 用于检测人C4d补体。
- 该抗体可用于发光法或用One Lambda 公司的LABScreen® Single Antigen beads流式检测细胞内或固相结合的C4或C4d片段。
- 检测样本:血清
- 来源:兔多克隆抗体
- 形式:50ul,PE 标记纯化的IgG片段。
参考文献:
1. C4d deposition is associated with inferior kidney allograft outcome independ.of cellular rejection. Regele H. et al., Nephrol Dial Transplant. 2001, 16(10): 2058-2066.
2. Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury. Böhmig GA et al., J Am Soc Nephrol. 2002, 13(4): 1091-1099.
3. [C4d]FlowPRA screening—a specific assay for selective detection of complement-activating anti-HLA alloantibodies. Wahrmann M et al., Hum Immunol, 2005, 66(5): 526-534
4. Pivotal role of complement-fixing HLA alloantibodies in presensitized kidney allograft recipients. Wahrmann M et al., Am J Transplant, 2006, 6: 1033-1041.
5. In vitro detection of C4d-fixing HLA alloantibodies: associations with capillary C4d deposition in kidney allografts. Bartel G et al., Am J Transplant, 2008, 8(1): 41-49
6. Antibodies, isotypes and complement in allograft rejection. Böhmig GA et al., Curr Opin Organ Transplant, 2008, 13(4): 411-418
7. Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients. Bartel G et al., Transpl Int. 2013; 26(2): 121-130.
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入驻年限:7年