Human Endostatin ELISA 人内皮抑制素ELISA试剂盒价格_品牌:Biomedica Immunoassay-丁香通官网

样本：血清、血浆

标记物：HRP

适应物种：人

应用：心血管疾病检测

检测方法：ELISA

检测限：0-80 nmol/L(0-1600ng/ml)

库存：1

供应商：北京博蕾德生物科技有限公司

规格：96T

Endostain ELISA Kit (BI-20742 )

背景简介：
Endostatin是一种内源性的血管生成抑制剂。Endostatin在受伤肾组织的肾小管细胞纤维化进程中高度表达。因此，Endostatin是慢性肾病检测的潜在标记物。对于微血管组织损伤病人包括：动脉硬化、脑缺血，Endostatin水平显著升高。
产品优势：

检测范围宽
6个即用型校准品
可当日检测，半小时内出结果
只需5ul样本
严格按照ICH要求，证实可用于人样本检测
可靠、重复性好的实验结果：批内＜6%，批间＜5%

试剂盒特点：
1）检测方法：夹心ELISA，96孔，HRP/TMB显色系统
2）样本类型：血清、血浆（柠檬酸盐抗凝、EDTA抗凝、肝素抗凝）、尿（参照对应的protocol）
3）样品量：5ul
4）标准品范围：0-80 nmol/L(0-1600ng/ml)
5）检测灵敏度：0.02nmol/L(0+3SD)
6）孵育条件：2h/1h/30min，室温
7）单位转换：1 ng/ml = 0.05 nmol/l (MW = 20 kDa)
8）特异性：人样本与其他种属无交叉反应
参考文献：

Elevated plasma levels of endostatin are associated with chronic kidney disease. J Chen, LL Hamm, et al.Am J Nephrol, Jan 2012; 35(4): 335-340
Early-onset coronary artery disease after pediatric kidney transplantation: implicatingthe angiogenesi inhibitor, endostatin. CW Iqbal,et al. Am Surg, Jun 2011; 77(6): 731-735
Immobilized kidney 28-kDa endostatin-related (KES28kDa) fragment promotes endothelial cell survival.MH Bellini, et al. Am J Nephrol, Jan 2010; 31(3): 255-261
Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Neel R. Sodha, et al.Am J Physiol Heart Circ Physiol, Feb 2009; 296: H428-H434

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该产品被引用文献

Endostatin Is an Independent Risk Factor of Graft Loss after Kidney Transplant.

Chu, C., Hasan, A.A., Gaballa, M.M.S., Zeng, S., Xiong, Y., Elitok, S., Krämer, B.K., Hocher, B., 2020. AJN 51, 373–380.

alidation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis.
Wallwitz, J., Aigner, P., Gadermaier, E., Bauer, E., Casanova, E., Bauer, A., Stoiber, D., 2019. PLoS One 14.

PMID: 31404120; PMCID: PMC6690585

Higher Parathyroid Hormone Level Is Associated With Increased Arterial Stiffness in Type 1 Diabetes.
Zobel, E.H., Theilade, S., Scholten, B.J. von, Persson, F., Tarnow, L., Lajer, M., Hansen, T.W., Rossing, P., 2017. Diabetes Care 40, e32–e33.

Endostatin in Chronic Kidney Disease: Associations with Inflammation, Vascular Abnormalities, Cardiovascular Events and Survival.

Kanbay, Mehmet, Baris Afsar, Dimitrie Siriopol, Hilmi Umut Unal, Murat Karaman, Mutlu Saglam, Mustafa Gezer, 2016 European Journal of Internal Medicine : 81–87.

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