PHAR4 Antibody (C-term) | LBP84477 | Leading Biology

保存条件 ：存储在2 - 8°C 2周，长期存储-20°C,防止冻融循环。

英文名 ：PHAR4 Antibody (C-term)

供应商 ：安诺伦（北京）生物科技有限公司

规格 ：400 μl

商品分类：多克隆抗体

产品概述：This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.

靶点/蛋白：This PHAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PHAR4.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Allen, P.B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(18):7187-7192(2004)Sagara, J., et al. J. Biol. Chem. 278(46):45611-45619(2003)

特异性：Human

别名：Phosphatase and actin regulator 4, PHACTR4

应用：WB~~1:1000

简单描述：Rabbit Polyclonal PHAR4 Antibody (C-term). Validated for use in WB, E.

详情：FunctionRegulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).Cellular_LocationCytoplasm. Cell projection, lamellipodium

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层