AFAP1-Y451 Antibody | LBP81650 | Leading Biology

保存条件 ：存储在2 - 8°C 2周，长期存储-20°C,防止冻融循环。

英文名 ：AFAP1-Y451 Antibody

供应商 ：安诺伦（北京）生物科技有限公司

规格 ：400 μl

商品分类：多克隆抗体

产品概述：Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

靶点/蛋白：This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 444-477 amino acids from human.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Han B.,et al.J. Biol. Chem. 279:54793-54801(2004).Ota T.,et al.Nat. Genet. 36:40-45(2004).Hillier L.W.,et al.Nature 434:724-731(2005).Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.Olsen J.V.,et al.Cell 127:635-648(2006).

特异性：Human

别名：Actin filament-associated protein 1, 110 kDa actin filament-associated protein, AFAP-110, AFAP1, AFAP

应用：WB~~1:1000

简单描述：Rabbit Polyclonal AFAP1-Y451 Antibody. Validated for use in WB, E.

详情：FunctionCan cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.Cellular_LocationCytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their inductionTissue_LocationLow expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层