PIK3R1 / p85 Alpha Antibody (clone 6G10) | LM17555 | Leading Biology

英文名 ：PIK3R1 / p85 Alpha Antibody (clone 6G10)

供应商 ：安诺伦（北京）生物科技有限公司

规格 ：50 μg

商品分类：单克隆抗体

产品概述：Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

靶点/蛋白：Human PIK3R1 / p85 Alpha

来源：Mouse

参考文献：Skolnik E.Y.,et al.Cell 65:83-90(1991).Antonetti D.A.,et al.Mol. Cell. Biol. 16:2195-2203(1996).Udelhoven M.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004).Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

特异性：Human

别名：Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1, GRB1

应用：ELISA (1:10000), Flo (1:200-1:400), ICC (1:100), IHC-P (1:200), WB (1:500-1:2000)

简单描述：Mouse Monoclonal PIK3R1 / p85 Alpha Antibody (clone 6G10). Validated for use in WB, IHC-P, IF, ICC, E, Flo. Clone: 6G10.

详情：FunctionBinds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).Tissue_LocationIsoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)

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企业 QQ：3212874516、3198592576

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