Histone Deacetylase 3 Antibody (C-term) | LM17127 | Leading Biology

保存条件 ：存储于2 - 8°C长达6个月。长期应存储存储在-20°，避免反复冻融。

英文名 ：Histone Deacetylase 3 Antibody (C-term)

供应商 ：安诺伦（北京）生物科技有限公司

规格 ：100 μl

商品分类：单克隆抗体

产品概述：Histone deacetylase 3 belongs to the histone deacetylase family type 1 which actively deacetylate Histones. Currently 3 known isoforms exists (HDAC3, HDAC3A and HDAC3C) (1). HDAC3 represses transcription and binds transcription factor YY1 to form a large complex. N-Cor binds HDAC3 in a different manner than other HDACs. In addition to N-Cor, HDAC3 will form a complex with corepressor SMRT (2). HDAC3 is also known to interact with DAXX, HDAC10 and DACH1.

靶点/蛋白：A synthetic peptide corresponding to residues in the C-term of human Histone deacetylase 3 was used as immunogen. This antibody may detect splice isoform 2 (RPD3-2A).

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. Wen-Ming Yang , Ya-Li Yao , Jian-Min Sun, James R. Davie and Edward Seto. Volume 272, Number 44, Issue of October 31, 1997 pp. 28001-28007
2. Li, J., Wang, J., Nawaz, Z., Liu, J.M., Qin, J. and Wong, J., 2000. EMBO J. 19, pp. 4342


特异性：Human, Mouse, Rat

别名：Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3

应用：WB~~1:500IHC~~1:250~500

简单描述：Rabbit Monoclonal Histone Deacetylase 3 Antibody (C-term). Validated for use in WB, IHC, IF. Clone: Y415.

详情：FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).Cellular_LocationNucleus. Cytoplasm. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803).Tissue_LocationWidely expressed.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

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