Anti-P Glycoprotein,P-gp

克隆性 ：多克隆

抗体英文名 ：Anti-P Glycoprotein

适应物种 ：Mouse, Rat, Human

应用范围 ： IHC-FoFr, IHC-P, WB

规格 ：40 µl

Anti-P Glycoprotein,P-gp
货号：ab170904
适用于: IHC-FoFr, IHC-P, WB
不适用于: ICC/IF
与反应: Mouse, Rat, Human
P-glycoprotein 1 (also known as Multidrug resistance protein 1) has a predicted molecular weight of 141 kDa, however it has 3 potential glycosylation sites (N-linked) which may affect the migration of the protein. In our hands ab170904 detects a predominant protein band migrating in the region of 180-200 kDa and typically will demonstrate a smear on the membrane in the region of the 150 – 300 kDa due to the glycosylation profile of the protein. It may be necessary to optimise your cell or tissue lysis protocol to efficiently extract P-glycoprotein 1 as it is a multi-pass membrane protein. Abcam recommends not boiling the sample after lysis. Please note that we do not recommend this antibody for use in IHC-P on mouse or rat tissue

文献：

• Seaman S  et al. Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell 31:501-515.e8 (2017). Read more (PubMed: 28399408) »
• Zhang C  et al. Growth of tyrosine kinase inhibitor-resistant Philadelphia-positive acute lymphoblastic leukemia: Role of bone marrow stromal cells. Oncol Lett 13:2059-2070 (2017). WB . Read more (PubMed: 28454362) »