免疫原 ：见官方网站

亚型 ：见官方网站

形态 ：液体或冻干粉

保存条件 ：-20°C

克隆性 ：多克隆

标记物 ：见官方网站

适应物种 ：见官方网站

保质期 ：6个月

抗原来源 ：见说明书

目录编号 ：ESD-750

级别 ：高

库存 ：大量

供应商 ：上海信裕生物科技有限公司

宿主 ：见说明书

应用范围 ：见官方网站

浓度 ：见官方网站

靶点 ：见官方网站

抗体英文名 ：NMDA Receptor 2B Deluxe Research Pack

抗体名 ：NMDA Receptor 2B Deluxe Research Pack

规格 ：11 Vials

NMDA Receptor 2B Deluxe Research Pack

All You Need for NMDA Receptor 2B Research
Cat #: ESD-750
11 Vials

Alomone Labs is pleased to offer the NMDA Receptor 2B Deluxe Research Pack (#ESD-750). The Research Pack contains all you need for NMDA receptor 2B research: NR2B-specific antibody and NMDA receptor pharmacological tools all in one economical package!

• Compounds
• Scientific Background
• Related Products

Product Name	Cat #	Size
Anti-NMDA Receptor 2B (GluN2B) (extracellular)	AGC-003	1 x 0.2 ml
Anti-NMDA Receptor 2B (GluN2B) (extracellular)-ATTO-594	AGC-003-AR	1 x 50 µl
7-Chlorokynurenic acid sodium salt	C-286	1 x 25 mg
D-AP5	D-145	1 x 25 mg
5,7-Dichlorokynurenic acid	D-190	1 x 50 mg
(+)-MK 801 maleate	M-230	1 x 50 mg
NMDA	N-170	1 x 250 mg
PEAQX tetrasodium hydrate	P-255	1 x 10 mg
trans-ACBD	A-280	1 x 10 mg

Scientific Background 

The NMDA receptors are members of the glutamate receptor family of ion channels that also include the AMPA and Kainate receptors.

The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.

The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg²⁺. Neuronal depolarization relieves the Mg²⁺ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca²⁺ influx differing from the other glutamate receptor ion channels that are non-selective cation channels.

Ca²⁺ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s disease.

NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.

NMDA Receptor 2B Deluxe Research PackReferences 

1. Dingledine, R. et al. (1999) Pharmacol. Rev. 51, 7.
2. Mayer, M.L. and Armstrong, N. (2004) Annu. Rev. Physiol. 66, 161.
3. Prybylowski, K. and Wenthold, R.J. (2004) J. Biol. Chem. 279, 9673.
4. Mayer, M.L. (2006) Nature 440, 456.