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库存 ：99
供应商 ：江蓝纯
规格 ： 50ul/ 100ul
| 英文名称 | Rabbit DCTN1 Polyclonal Antibody |
|---|---|
| 别名 | CD246;NBLST3 |
| 应用 | WB,IHC,IF |
| 稀释比例 | WB1:500-1:2000 IHC1:50-1:200 IF1:10-1:100 |
| 交叉反应 | Human,Mouse,Rat |
| 蛋白分子量 | 142kDa |
| Gene ID | 1639 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
| 储存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DCTN1 |
| 性状 | Lyophilized or Liquid |
| Swiss Prot | Q14203 |
| 克隆类型 | Polyclonal Antibody |
| 来源 | Rabbit |
| 背景资料 | This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). |
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入驻年限：8年
