免疫原 ：见官方网站

亚型 ：见官方网站

形态 ：液体或冻干粉

保存条件 ：-20°C

克隆性 ：多克隆

标记物 ：见官方网站

适应物种 ：见官方网站

保质期 ：6个月

抗原来源 ：Synthetic

目录编号 ：G-165

级别 ：高

库存 ：大量

供应商 ：上海信裕生物科技有限公司

宿主 ：Synthetic

应用范围 ：见官方网站

浓度 ：见官方网站

靶点 ：见官方网站

抗体英文名 ：2-GMQ hydrochloride

抗体名 ：2-GMQ hydrochloride

规格 ：5 mg, 10 mg, 50 mg, 250 mg

2-GMQ hydrochloride

An ASIC Channel Modulator and an ASIC3 Channel Opener
Cat #: G-165
Sizes: 5 mg, 10 mg, 50 mg, 250 mg
Source: Synthetic
MW: 237.1 Da.
Target: ASIC1a, ASIC2, ASIC3
CLICK HERE TO RECEIVE A 5 mg FREE TRIAL SAMPLE!

2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied^1,2.

GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition GMQ contains a guanidinium group and a heterocyclic ring.

Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner³.

Alomone Labs is pleased to offer 2-GMQ hydrochloride (#G-165).

2-GMQ hydrochlorideReferences

1. Alijevic, O. and Kellenberger, S. (2012) J. Biol. Chem. 287, 36059.
2. Li, W.G. et al. (2010) Mol. Pain 88, 1186.
3. Li, W.G. et al. (2011) J. Biol. Chem. 286, 42635.

• Our Bioassay
• Specifications
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Our bioassay

Alomone Labs 2-GMQ hydrochloride modulates ASIC3 channels expressed in Xenopus oocytes. 
Time course of ASIC3 currents elicited by stimulation with pH 6 every 50 sec, while membrane potential was held at -60 mV. 0.5 mM 2-GMQ hydrochloride (#G-165), applied for 3.5 min, as indicated causes reversible complex effect combining peak amplitude depression with diminished inactivation, as seen with superimposed traces in B.
Purity>99%.
Effective concentration1-5 mM
Chemical name2-(4-methylquinazolin-2-yl)guanidine hydrochloride.
Molecular formulaC₁₀H₁₂ClN₅.
CAS number5361-15-9.
Activity2-GMQ is an ASIC modulator, ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -3¹.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to four weeks at 4°C or three months at -20°C.