免疫原 ：见官方网站

亚型 ：见官方网站

形态 ：液体或冻干粉

保存条件 ：-20°C

克隆性 ：多克隆

标记物 ：见官方网站

适应物种 ：见官方网站

保质期 ：6个月

抗原来源 ：见官方网站

目录编号 ：STJ-400

库存 ：大量

供应商 ：上海信裕生物科技有限公司

宿主 ：见官方网站

应用范围 ：见官方网站

浓度 ：见官方网站

靶点 ：见官方网站

抗体英文名 ：Jingzhaotoxin XI

抗体名 ：Jingzhaotoxin XI

规格 ：50 µg, 0.1 mg, 0.5 mg, 1 mg, 5 mg

Jingzhaotoxin XI

Jingzhaotoxin XI, JzTx-XI, κ-theraphotoxin-Cg1a 1, κ-TRTX-Cg1a, Jingzhaotoxin-11, JZTX-11, Jingzhaotoxin-XI, JZTX-XI
A Blocker of Na_V1.5 and K_V2.1 Channels
Cat #: STJ-400
Sizes: 50 µg, 0.1 mg, 0.5 mg, 1 mg, 5 mg
Source: Synthetic peptide
MW: 3726 Da.
Net Peptide Content: 100%
Target: K_V2.1 and Na_V1.5 channels
CLICK HERE TO RECEIVE A 50 µg FREE TRIAL SAMPLE!

Jingzhaotoxin XI (JzTx-XI) is a 34-residue peptide toxin originally isolated from the Chinese tarantulaChilobrachys jingzhao venom. Jingzhaotoxin XI toxin can potently inhibits both voltage-gated Na⁺ channelNa_V1.5 with an IC₅₀ value of 124 ± 26 nM and voltage-gated K⁺ channel K_V2.1 with an IC₅₀ value of 390 ± 60 nM^1,2,3.

The mature toxin contains six cysteine residues linked through disulfide bridges and a hydrophobic patch surrounded by charged residues such as Arg or Lys. Jingzhaotoxin XI is a useful tool for investigating the promiscuity of spider toxins².

K_V2.1 channels play an important role in neuronal systems including the neural retina. The channel’s functions include regulation of neuronal excitability and neural transmitter release⁴.

Na_V1.5 channels are important in generating and propagating action potentials in excitable cells, in working myocardium and cardiac tissue conduction cells⁵.

Alomone Labs is pleased to offer Jingzhaotoxin XI (#STJ-400), a highly purified synthetic peptide.

References

1. Tao, H. et al. (2016) Toxicon 124, 8.
2. Liao, Z. et al. (2006) Biochemistry 45, 15591.
3. Tang, C. et al. (2014) Toxicon 92, 6.
4. Liu, X. et al. (2017) Oncotarget 8, 59345.
5. Wang, J. et al. (2017) Mol. Med. Rep. 16, 719. 

• Our Bioassay
• Specifications
• Related Products

Our bioassay

Alomone Labs Jingzhaotoxin XI blocks K_V2.1 channels expressed in Xenopus oocytes.
A. Representative time course of Jingzhaotoxin XI (#STJ-400) inhibition of K_V2.1 current. Membrane potential was held at -80 mV, current was elicited by a 300 ms voltage step to +10 mV every 10 sec, and inhibited by 0.1 µM and 1 µM Jingzhaotoxin XI, applied as indicated by horizontal bars. B. Superimposed traces of K_V2.1 current after the application of control, 0.1 µM and 1 µM Jingzhaotoxin XI (taken from experiment in A).

Alomone Labs Jingzhaotoxin XI blocks Na_V1.5 channels expressed in Xenopus oocytes.
A. Representative time course of Jingzhaotoxin XI (#STJ-400) inhibition of Na_V1.5 current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage ramp to +40 mV every 10 sec, and inhibited significantly by 1 µM Jingzhaotoxin XI. B. Superimposed traces of Na_V1.5 current following the application of control and of 1 µM Jingzhaotoxin XI (taken from experiment in A).
OriginChilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao).
Purity>98%.
FormulationLyophilized powder.
Effective concentration0.5-1 µM.
SequenceECRKMFGGCSVDSDCCAHLGCKPTLKYCAWDGTF.
ModificationsDisulfide bonds between Cys²- Cys¹⁶, Cys⁹- Cys^21, Cys¹⁵- Cys²⁸. C-terminal amidation at Phe³⁴.
Molecular formulaC₁₅₈H₂₃₄N₄₄O₄₇S₇.
CAS numberNot determined.
Accession numberP0C247.
ActivityJingzhaotoxin XI is voltage-gated Na⁺ channel Na_V1.5 with an IC₅₀ value of 124 ± 26 nM and voltage-gated K⁺ channel K_V2.1 with an IC₅₀ value of 390 ± 60 nM¹.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionAny aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitutionUp to two weeks at 4°C or three months at -20°C.
Related products 

1. Anti-Na_V1.5 (#ASC-005)
2. Anti-Human Na_V1.5 (#ASC-013)
3. Guinea pig Anti-Na_V1.5 (#AGP-008)
4. Anti-K_V2.1 (#APC-012)
5. Guinea pig Anti-K_V2.1 (#AGP-109)
6. Guangxitoxin-1E (#STG-200)
7. Stromatoxin-1 (#STS-350)
8. ProTx-I (#STP-400)
9. Jingzhaotoxin-II (#STJ-150)
10. Jingzhaotoxin-III (#STJ-200)
11. Jingzhaotoxin-XII (#STJ-100)