免疫原 ：见说明书

亚型 ：见说明书

形态 ：冻干粉/液体

保存条件 ：4-8ºC without exposure to light. No precautions necessary during handling.

克隆性 ：多克隆

标记物 ：见说明书

适应物种 ：见说明书

保质期 ：12个月

抗原来源 ：Human

目录编号 ：ABS 002-49

级别 ：见说明书

库存 ：大量

供应商 ：上海信裕生物科技有限公司

宿主 ：Human

应用范围 ：ELISA, IF

浓度 ：见说明书

靶点 ：见说明书

抗体英文名 ：Anti-Complement component C1s (human, pro- and activated enzyme)

抗体名 ：Anti-Complement component C1s (human, pro- and activated enzyme)

规格 ：200ug/1mg

Anti-Complement component C1s (human, pro- and activated enzyme)

Cat. No.

ABS 002-49

Product name

Anti-Complement component C1s (human, pro- and activated enzyme)

Description

Mouse monoclonal antibody

Specificity

ABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor.

Immunogen

Human plasma C1s Proenzyme

Application

ELISA, IF

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG1/k

Gene ID

716

Clone number

49

Epitope

Epitope differs from that of ABS 002-09

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.