Anti-Complement component C1s (human, pro- and activated enzyme)

价格： $410

品牌：BioPorto

货号：ABS 002-096

产品详情

Anti-Complement component C1s (human, pro- and activated enzyme)

Bioporto是一家体外诊断公司，专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。
官方网站：www.bioporto.com

Cat. No.

ABS 002-096

Product name

Anti-Complement component C1s (human, pro- and activated enzyme)

Description

Mouse monoclonal antibody

Specificity

ABS 002-09 is specific for C1s proenzyme and activated free C1s

Immunogen

C1s proenzyme purified from human plasma

Application

ELISA, IHC

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG1/k

Gene ID

716

Clone number

Epitope

Epitope differs from that of ABS 002-49

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

Protein-A purified

Form

Liquid

Solvent

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

4-8ºC without exposure to light. No precautions necessary during handling.

Target

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.

Application 1

ELISA

ABS 002-09 reacts in ELISA when tested with activated C1s enzyme directly coated onto the microtiter well or in sandwich ELISA in combination with a polyclonal antibody in coat.

Application 2

IHC

ABS 002-09 was used in immunohistochemistry