血根碱水合物 ,≥98%(HPLC)

保质期 ：两年

英文名 ：Sanguinarine chloride hydrate

库存 ：99

供应商 ：江蓝纯

CAS号 ：5578-73-4 ,2447-54-3

规格 ：50mg/250mg

属性

熔点	277-280°C
溶解性	Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM).

描述

产品介绍	Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
别名	氯化血根碱;血根碱盐酸盐;
备注	CAS Number: 5578-73-4 (anhydrous),Formula weight and CAS # are for anhydrous basis.
应用	一个具有抗菌，消炎，抗氧化性能的天然产物。有抑制肿瘤细胞株扩增和促凋亡作用。 A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor