Recombinant Human PDGF R beta/CD140b

英文名 ：Recombinant Human PDGF R beta/CD140b

规格 ：10ug/50ug/500ug/1mg

Recombinant Human PDGF R beta/CD140b  (C380)

 

产品说明(Description)

Recombinant Human Platelet-Derived Growth Factor Receptor beta is produced by our Mammalian expression system and the target gene encoding Leu33-Phe530 is expressed with a 6His tag at the C-terminus. 

Accession #: AAH32224.1

Known as: Platelet-Derived Growth Factor Receptor Beta; PDGF-R-Beta; PDGFR-Beta; Beta Platelet-Derived Growth Factor Receptor; Beta-Type Platelet-Derived Growth Factor Receptor; CD140 Antigen-Like Family Member B; Platelet-Derived Growth Factor Receptor 1; PDGFR-1; CD140b; PDGFRB; PDGFR; PDGFR1

 

制剂（Formulation）

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

 

质量控制（Quality Control） 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

复溶（Reconstitution）

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

 

保存（Storage）

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.     

 

背景（Background）

Platelet-Derived Growth Factor Receptor β (PDGFR-β) is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells, and neutrophils and has been reported to be important in the modification of cellular matrix constituents.

 

电泳(SDS-PAGE)

 

FOR RESEARCH USE ONLY