Recombinant Human CD27 Ligand/CD70/TNFSF7

英文名 ：Recombinant Human CD27 Ligand/CD70/TNFSF7

规格 ：10ug/50ug/500ug/1mg

Recombinant Human CD27 Ligand/CD70/TNFSF7  (CI06)

 

产品说明(Description)

Recombinant Human CD27 Ligand/CD70 is produced by our Mammalian expression system and the target gene encoding Gln45-Pro193 is expressed with a Fc tag at the C-terminus. 

Accession #: P32970

Known as: CD70 antigen;CD70;CD27 ligand;Tumor necrosis factor ligand superfamily member 7;CD27LG; TNFSF7;CD27L

 

制剂（Formulation）

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

 

质量控制（Quality Control） 

Purity:            Greater than 90% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

复溶（Reconstitution）

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

 

保存（Storage）

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.     

 

背景（Background）

CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

 

电泳(SDS-PAGE)
 

参考文献(References)

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration[J]. Mi Deng. et al. nature. 2018.

 

FOR RESEARCH USE ONLY