Recombinant Human PMM2/Phosphomannomutase 2

英文名 ：Recombinant Human PMM2/Phosphomannomutase 2

规格 ：10ug/50ug/500ug/1mg

Recombinant Human PMM2/Phosphomannomutase 2  (C250)

 

产品说明(Description)

Recombinant Human Phosphomannomutase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ser246 is expressed with a 6His tag at the C-terminus. 

Accession #: O15305

Known as: Phosphomannomutase 2; PMM 2; PMM2

 

制剂（Formulation）

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

 

质量控制（Quality Control） 

 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

 

运输（Shipping）

The product is shipped on dry ice/polar packs. 

Upon receipt, store it immediately at the temperature listed below.  

 

保存（Storage）

Store at ≤-70°C, stable for 6 months after receipt. 

Store at ≤-70°C, stable for 3 months under sterile conditions after opening. 

Please minimize freeze-thaw cycles.

 

背景（Background）

Phosphomannomutase 2 (PMM2) is an enzyme that is a member of the highly variable methyltransferase superfamily. PMM2 is a cytoplasmic protein and catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate.In addition, PMM2 involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose that required for a number of critical mannosyl transfer reactions. Defects in PMM2 can results in congenital disorder of glycosylation type 1A (CDG1A). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation.

 

电泳(SDS-PAGE)

 

FOR RESEARCH USE ONLY