Recombinant Human Hyaluronidase-1/HYAL1

英文名 ：Recombinant Human Hyaluronidase-1/HYAL1

规格 ：10ug/50ug/500ug/1mg

Recombinant Human Hyaluronidase-1/HYAL1  (CA81)

 

产品说明(Description)

Recombinant Human Hyaluronidase-1 is produced by our Mammalian expression system and the target gene encoding Phe22-Trp435 is expressed with a 6His tag at the C-terminus. 

Accession #: Q12794

Known as: Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung Carcinoma Protein 1; LuCa-1; HYAL1; LUCA1

 

制剂（Formulation）

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10%Glycerol, pH7.5.

 

质量控制（Quality Control） 

 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

 

运输(Shipping)

The product is shipped on dry ice/polar packs. 
Upon receipt, store it immediately at the temperature listed below.

 

保存(Storage)

Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening. 
Please minimize freeze-thaw cycles.     

 

背景（Background）

Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

 

电泳(SDS-PAGE)

 

参考文献(Reference)

1、Targeted delivery of doxorubicin to tumour tissues by a novel legumain sensitive polygonal nanogel. Sen Lina. et al. Nano Scale. 2016.

 

 

FOR RESEARCH USE ONLY