Recombinant Human Cyr61/CCN1

英文名 ：Recombinant Human Cyr61/CCN1

规格 ：10ug/50ug/500ug/1mg

Recombinant Human Cyr61/CCN1  (CB98)

 

产品说明(Description)

Recombinant Human Cysteine-rich angiogenic inducer 61 is produced by our Mammalian expression system and the target gene encoding Thr25-Asp381 is expressed with a Fc tag at the C-terminus. 

Accession #: O00622

Known as: Protein CYR61;CCN family member 1; Cysteine-rich angiogenic inducer 61;Insulin-like growth factor-binding protein 10 ; GIG1; CYR61; CCN1;IGFBP10; 

 

制剂(Formulation)

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

 

质量控制(Quality Control)

 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

复溶(Reconstitution)

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

 

保存(Storage)

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.     

 

背景(Background)

Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain and  one VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

 

电泳(SDS-PAGE)

 

 

参考文献(Reference)

 

The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells[J]. Gang Gong. et al. Oxidative Medicine and Cellular Longevity. 2021.

 

FOR RESEARCH USE ONLY