PeproTech重组小鼠IL-21(无动物成分) 2ug

PeproTech重组小鼠IL-21(无动物成分) 2ug

价格: ¥1250

品牌:PeproTech 品牌认证

货号:AF-210-21-2

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年限 :一年以上

运输方式 :4度

英文名 :Murine IL-21

库存 :大量

供应商 :PeproTech(派普泰克)

CAS号 :

规格 :2ug

Description:

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.

Manufactured using all Animal-Free reagents.

Source:E.coli

Synonyms:Interleukin-21, Za11

AA Sequence:MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.

派普泰克生物科技(苏州)有限公司(PeproTech中国)

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入驻年限:15年

联系人:赛默飞世尔科技(中国)有限公司

地址:上海

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