文献支持NFκB-p65 Polyclonal Antibody_货号:E-AB-32233_多克隆抗体
价格: ¥420 - 2365
产品详情
文献和实验
相关推荐
抗体名 :NFκB-p65 Polyclonal Antibody_货号:E-AB-32233_多克隆抗体
抗体英文名 :NFκB-p65 Polyclonal Antibody
应用范围 :WB;IHC-p;ELISA
宿主 :Rabbit
适应物种 :Human;Mouse;Rat
保质期 :12个月
目录编号 :E-AB-32233
级别 :科研级别
库存 :999
供应商 :武汉伊莱瑞特生物科技股份有限公司
标记物 :Unconjugated
克隆性 :Polyclonal
保存条件 :Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
形态 :液体
亚型 :IgG
规格 :200μL/120μL/60μL/20μL
产品名称:NFκB-p65 Polyclonal Antibody货号:E-AB-32233
Verified Samples |
Verified Samples in WB:KB,Hela,293T,3T3
Verified Samples in IHC:Human stomach cancer,Mouse kidney |
Dilution |
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
|
Clonality |
Polyclonal
|
Isotype |
IgG
|
Immunogen |
Synthesized peptide derived from human NFκB-p65 around the non-phosphorylation site of Ser281.
|
Abbre |
NFκB-p65
|
Synonyms |
Avian reticuloendotheliosis viral (v rel) oncogene homolog A;MGC131774;NF kappa B p65delta3;NFKB3;Nuclear Factor NF Kappa B p65 Subunit;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B cells 3;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;OTTHUMP00000233473;OTTHUMP00000233474;OTTHUMP00000233475;OTTHUMP00000233476;OTTHUMP00000233900;p65;p65 NF kappaB;p65 NFkB;relA;TF65;Transcription factor p65;v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65));V rel avian reticuloendotheliosis viral oncogene homolog A;v rel reticuloendotheliosis viral oncogene homolog A (avian);V rel reticuloendotheliosis viral oncogene homolog A;nuclear factor of kappa light polypeptide gene enhancer in B cells 3;p65抗体
|
Swissprot |
Q04206
|
Calculated MW |
60kDa
|
Observed MW |
60kDa
|
Cellular Localization |
Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalized with RELA in the nucleus upon TNF-alpha induction.
|
Concentration |
1 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
|
Purification Method |
Affinity purification
|
Research Areas |
Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Neuroscience; Signal Transduction
|
Conjugation |
Unconjugated
|
Background |
Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel,are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.
|
武汉伊莱瑞特生物科技股份有限公司
品牌商实名认证
钻石会员
入驻年限:10年