InVivoPlus anti-mouse PD-1 (CD279) 有现货

抗体名 ：InVivoPlus anti-mouse PD-1 (CD279)

抗体英文名 ：InVivoPlus anti-mouse PD-1 (CD279)

靶点 ：请见产品说明书

浓度 ：请见产品说明书

应用范围 ：in vivo blocking of PD-1/PD-L signaling

宿主 ：Rat

适应物种 ：Mouse

保质期 ：请参考说明书

库存 ：大量

供应商 ：欣博盛生物科技有限公司

标记物 ：无

克隆性 ：单克隆

保存条件 ：4度避光

形态 ：液体

亚型 ：Rat IgG2a

免疫原 ：mouse PD-1 (CD279)

规格 ：100 mg

产品介绍：
The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance. Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

推荐的同型对照：InVivoPlus rat IgG2a isotype control, anti-trinitrophenol(BP0089)

免疫原：Syrian Hamster BKH cells transfected with mouse PD-1 cDNA

内毒素水平：

• <1EU/mg (<0.001EU/μg)
• Determined by LAL gel clotting assay

纯度：

• >95%
• Determined by SDS-PAGE

组成：

• PBS, pH 7.0
• Contains no stabilizers or preservatives

蛋白分子量大小：150 kDa

保存条件：
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

参考文献：
1.Grasselly, C., et al. (2018). "The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent." Front Immunol 9: 2100.
2.Triplett, T. A., et al. (2018). "Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme." Nat Biotechnol 36(8): 758-764.
3.Moynihan, K. D., et al. (2016). "Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses." Nat Med. doi: 10.1038/nm.4200.
4.Evans, E. E., et al. (2015). "Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies." Cancer Immunol Res 3(6): 689-701

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