产品详情
文献和实验
相关推荐
英文名 :Recombinant Human MMP-2
库存 :大量
供应商 :PeproTech(派普泰克)
CAS号 :无
Synonyms : |
Matrix metalloproteinase-2; Gelatinase A, TBE-1 |
||||||||||||||||||||||||
Description : |
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids). |
||||||||||||||||||||||||
Catalog #: |
420-02 |
||||||||||||||||||||||||
Source : |
E.coli |
||||||||||||||||||||||||
Purity : |
Greater than 90% by SDS-PAGE gel and HPLC analyses. |
||||||||||||||||||||||||
Endotoxin Level : |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
||||||||||||||||||||||||
Biological Activity : |
MMP-2 activity was measured by its ability to cleave a chromogenic peptide MMP-2 substrate at room temperature. At an MMP-2 concentration of 2.5 μg/ml, 50% cleavage was achieved at an incubation time of approximately 25 minutes. |
||||||||||||||||||||||||
AA Sequence : |
MYNFFPRKPK WDKNQITYRI IGYTPDLDPE TVDDAFARAF QVWSDVTPLR FSRIHDGEAD IMINFGRWEH GDGYPFDGKD GLLAHAFAPG TGVGGDSHFD DDELWTLGEG QVVRVKYGNA DGEYCKFPFL FNGKEYNSCT DTGRSDGFLW CSTTYNFEKD GKYGFCPHEA LFTMGGNAEG QPCKFPFRFQ GTSYDSCTTE GRTDGYRWCG TTEDYDRDKK YGFCPETAMS TVGGNSEGAP CVFPFTFLGN KYESCTSAGR SDGKMWCATT ANYDDDRKWG FCPDQGYSLF LVAAHEFGHA MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC |
||||||||||||||||||||||||
PubMed Link : |
|||||||||||||||||||||||||
Country of Origin : |
USA |
||||||||||||||||||||||||
|
|
||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Special Sizes: |
||||||||||||||||||||||||
|
Usage: |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
品牌商实名认证
钻石会员
入驻年限:15年