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库存 :大量
CAS号 :无
英文名 :Recombinant Human TNF-alpha
供应商 :PeproTech(派普泰克)
Synonyms : |
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin |
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Description : |
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. |
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Catalog #: |
300-01A |
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Source : |
E.coli |
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Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin Level : |
Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
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Biological Activity : |
The ED 50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. |
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Selected References : |
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AA Sequence : |
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL |
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PubMed Link : |
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Country of Origin : |
USA |
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Special Sizes: |
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Usage: |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
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入驻年限:15年