产品详情
文献和实验
相关推荐
保存条件 :-20oC
保质期 :1年以上
供应商 :PeproTech(派普泰克)
CAS号 :无
英文名 :Recombinant Human IL-4
库存 :大量
用途/可能作用机制:免疫逃逸的可能机 制研究,DC疫苗的研发
Synonyms : |
BCGF, BCDF, B cell stimulating factor (BSF-1) |
||||||||||||||||
Description : |
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.Manufactured using all non-animal reagents. |
||||||||||||||||
Catalog #: |
AF-200-04 |
||||||||||||||||
Source : |
E.coli |
||||||||||||||||
Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
||||||||||||||||
Endotoxin Level : |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
||||||||||||||||
Biological Activity : |
The ED 50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. |
||||||||||||||||
AA Sequence : |
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS |
||||||||||||||||
PubMed Link : |
|||||||||||||||||
Country of Origin : |
USA |
||||||||||||||||
|
|||||||||||||||||
|
|
||||||||||||||||
|
|
||||||||||||||||
|
Special Sizes: |
||||||||||||||||
|
Usage: |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
品牌商实名认证
钻石会员
入驻年限:15年