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保存条件 :-20oC
CAS号 :无
英文名 :Recombinant Human PDGF-BB
保质期 :1年以上
供应商 :PeproTech(派普泰克)
库存 :大量
PeproTech为研发机构提供高质量的科研产品,支持病毒研究及治疗性抗体开发,共同努力 打赢这场新型冠状病毒狙击战。 |
用途/可能作用机制:降低炎症反应,减少炎性渗出,增强肺泡毛细血管内皮细胞存活率, 改善肺部环境,减轻病毒感染患者的病情 |
Synonyms : |
Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) |
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Description : |
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). Manufactured using all non-animal reagents . |
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Catalog #: |
AF-100-14B |
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Source : |
E.coli |
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Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin Level : |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
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Biological Activity : |
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED 50 for this effect is 1.0-3.0 ng/ml. |
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AA Sequence : |
SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT |
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PubMed Link : |
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Country of Origin : |
USA |
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Special Sizes: |
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Usage: |
派普泰克生物科技(苏州)有限公司(PeproTech中国)
品牌商实名认证
钻石会员
入驻年限:15年