Human CD3 epsilon & CD3 delta Heterodimer Protein, His Tag&Tag Free

英文名 ：Human CD3 epsilon & CD3 delta Heterodimer Protein, His Tag&Tag Free

供应商 ：ACROBiosystems

规格 ：1mg/50ug

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>90% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Mouse Anti-Human CD3 (SP34-2) at 5 μg/mL (100 μL/well) can bind Human CD3E&CD3D Heterodimer Protein, His Tag&Tag Free (Cat. No. CDD-H52W4) with a linear range of 0.3-5 ng/mL (QC tested). Measured by its binding ability in a functional ELISA. Immobilized Human CD3E&CD3D Heterodimer Protein, His Tag&Tag Free (Cat. No. CDD-H52W4) at 2 μg/mL (100 μL/well) can bind OKT3 (mouse IgG2a) with a linear range of 0.01-0.08 μg/mL (QC tested).

产品背景:
T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

产品描述:
Human CD3E&CD3D Heterodimer Protein, His Tag&Tag Free is produced by co-expression of CD3E and CD3D, has a calculated MW of 16.7 kDa (CD3E), 13.5 kDa (CD3D) . Subunit CD3E is fused with a polyhistidine tag at the C-terminus and subunit CD3D contains no tag. The predicted N-terminus is Asp 23 (CD3E) & Phe 22 (CD3D). The reducing (R) heterodimer protein migrates as 24-32 kDa (CD3E) and 22 kDa (CD3D) due to glycosylation.
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