CHEK2 Antibody (Phospho-Ser516) (OAAN02966)

抗体英文名 ：CHEK2 Antibody (Phospho-Ser516) (OAAN02966)

靶点 ：CHEK2

应用范围 ：WB

宿主 ：Rabbit

适应物种 ：Human

标记物 ：Unconjugated

克隆性 ：Polyclonal

保存条件 ：Store at -20C. Avoid repeated freeze/thaw cycles.

形态 ：Liquid

亚型 ：IgG

免疫原 ：A phospho-Serpecific peptide corresponding-Thro residues-Serurrounding-Ser516 of human CHEK2

规格 ：50ul

NCBI Gene Id: 11200
Swissprot Id: O96017
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAN02966

A549 Cells

Western blot analysis of extracts from A549 cells, using Phospho-CHEK2-S516 antibody.