PRKG1 Antibody (OALA09053)

抗体英文名 ：PRKG1 Antibody (OALA09053)

靶点 ：PRKG1

应用范围 ：IHC-P

宿主 ：Rabbit

适应物种 ：Chicken, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey

克隆性 ：Polyclonal

保存条件 ：For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

形态 ：Liquid

免疫原 ：A 15 residue synthetic peptide DEPPPDDNSGWDIDF based on the human PKG 1alpha (residues 657-671) and the peptide coupled to KLH. Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bat, Bovine, Horse,

规格 ：50 uL

NCBI Gene Id: 5592
Swissprot Id: Q13976
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OALA09053

Human Skeletal Muscle

Anti-PRKG1 / CGKI antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.