PRKG1 Antibody (OAGA01471)

抗体英文名 ：PRKG1 Antibody (OAGA01471)

靶点 ：PRKG1

应用范围 ：IHC-P, WB

宿主 ：Rabbit

适应物种 ：Human, Mouse

克隆性 ：Polyclonal

保存条件 ：Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

形态 ：Liquid. 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

亚型 ：IgG

免疫原 ：Recombinant protein encompassing a sequence within the center region of human cGK1. The exact sequence is proprietary.

规格 ：100 ul

NCBI Gene Id: 5592
Swissprot Id: Q13976
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAGA01471

Paraffin-embedded Endometrial CA

Immunohistochemical analysis of paraffin-embedded Endometrial CA, using cGK1 (OAGA01471) antibody at 1:500 dilution.

NIH-3T3

Sample (30 ug of whole cell lysate)
A: NIH-3T3
B: JC
7.5% SDS PAGE
OAGA01471 diluted at 1:2000