SETD8 Antibody - middle region (ARP75870_P050)

抗体英文名 ：SETD8 Antibody - middle region (ARP75870_P050)

靶点 ：SETD8

应用范围 ：WB

宿主 ：Rabbit

适应物种 ：Human

克隆性 ：Polyclonal

保存条件 ：Add 50 ul of distilled water. Final concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

形态 ：Lyophilized

免疫原 ：The immunogen is a synthetic peptide directed towards the middle region of Human SETD8

规格 ：50 ug

NCBI Gene Id: 387893
Swissprot Id: Q9NQR1
SETD8 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. It is involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Ans it plays a negative role in TGF-beta response regulation and a positive role in cell migration. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet_lyophilized.php?sku=ARP75870_P050

Human 293T Whole Cell

Host: Rabbit
Target Name: SETD8
Sample Type: 293T Whole Cell lysates
Antibody Dilution: 1.0ug/ml