Anti-BCL-2 Antibody (Phospho-Thr56) (OAAI00053)

抗体英文名 ：Anti-BCL-2 Antibody (Phospho-Thr56) (OAAI00053)

靶点 ：BCL2

应用范围 ：IHC, ELISA

宿主 ：Rabbit

适应物种 ：Human, Mouse

克隆性 ：Polyclonal

保存条件 ：The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity.
Avoid repeated freezing thawing cycles.

亚型 ：Rabbit IgG

免疫原 ：A synthetic peptide derived from epitope - GHTPH- with the phosphorylation site Thr56 of Human BCL-2 protein.

规格 ：100 ug

NCBI Gene Id: 596
Swissprot Id: P10415
The Bcl-2 gene codes for a 25 kDa protein which has been implicated in the control of cell death by apoptosis, in normal tissues, expression of bcl-2 is restricted to cells and tissues that are characterized by apoptotic cell turnover. Bcl-2 protein exerts a survival function in response to a wide range of apoptotic stimuli throμgh inhibition of mitochondrial cytochrome c release, thus it is also considered as an inner mitochondrial membrane protein which can be expressed in lymphoma and breast carcinoma cells. This protein modulates mitochondrial calcium homeostasis and proton flux. Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, Ser87 and Thr127 which may be the targets of the ASK1/MKK7/JNK1 pathway, and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes. Phosphorylation of Bcl- 2 at Ser70 by IL-3/JNK may be required for its enhanced antiapoptotic functions.
- See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OAAI00053

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