WISP1 Antibody - N-terminal region (ARP63883_P050)

抗体英文名 ：WISP1 Antibody - N-terminal region (ARP63883_P050)

靶点 ：WISP1

应用范围 ：WB

宿主 ：Rabbit

适应物种 ：Human

克隆性 ：Polyclonal

保存条件 ：Add 50 ul of distilled water. Final concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.

形态 ：Lyophilized

免疫原 ：The immunogen is a synthetic peptide directed towards the N terminal region of human WISP1

规格 ：50 ug

NCBI Gene Id: 8840
Swissprot Id: O95388
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet_lyophilized.php?sku=ARP63883_P050

Human Lung Tumor

Host: Rabbit
Target Name: WISP1
Sample Tissue: Human Lung Tumor lysates
Antibody Dilution: 1ug/ml