HIF2A Antibody (OASE00131)

抗体英文名 ：HIF2A Antibody (OASE00131)

靶点 ：EPAS1

应用范围 ：ELISA, WB, IHC, ICC, IF

宿主 ：Mouse

适应物种 ：Human, Mouse

克隆性 ：Monoclonal

保存条件 ：Store at -20C. Shipping in Blue Ice or 4C. Avoid freeze/thaw cycles.

形态 ：Liquid. Supplied in PBS pH7.4, 50% glycerol, 0.09% sodium azide.

亚型 ：IgG1

免疫原 ：GST-human EPAS-1 (HIF2alpha) amino acids 535-631 fusion protein

规格 ：25ug

NCBI Gene Id: 2034
Swissprot Id: Q99814
Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia (1). HIF2-Alpha is involved in catecholamine homeostasis, vascular remodeling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumour progression remains to be clarified (2). Studies suggest hat in the case of non-small cell lung cancer, HIF2-Alpha actually is a promoter of tumor growth and progression in a solid tumor (1). Other data suggests that HIF2-Alpha is an important regulator of innate immunity, and therefore may be useful in the therapeutic target for treating inflammatory disorders and cancer (3). - See more at: http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OASE00131

Mouse backskin sections

IHC analysis of HIF2 Alpha using mouse backskin sections.Courtesy of Dr. Turksen, Ottawa Hospital Research Institute.

CoCl treated HeLa lysates

Western blot analysis of HIF2 Alpha in CoCl treated HeLa lysates, using a 1:1000 dilution of OASE00131.