GSK3b ( 糖原合成酶激酶 3β) 质粒

GSK3B

名称: GSK3b; 糖原合成酶激酶 3β

描述: Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination,metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation。

糖元合成激酶3b(GSK3b)是一种参与了多种细胞活动的丝氨酸/色氨酸激酶. 其酪氨酸残基被磷酸化后表现出活化. Hartigan et al 首先证实GSK3b在体内和原位都是Pyk-2的作用底物. GSK3b的酪氨酸被磷酸化后表现出活性。Wnt信号途径中GSK3b的抑制导致β catenin的积累（β catenin在引导区中分布，参与星状胶质细胞迁移），而另外一个GSK的底物APC是极性形成必需的。

种属：mouse