Anti Cdc42 Rabbit Polyclonal Antibody

Anti Cdc42 Rabbit Polyclonal Antibody

价格： ¥2800

品牌：N&T Biosciences

货号：21010

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抗体名：抗Cdc42 兔多克隆抗体

抗体英文名：Anti-Cdc42 Rabbit Polyclonal Antibody

靶点：CDC42

浓度：0.2mg/ml

应用范围：WB

宿主：兔

适应物种：脊椎动物

保质期：1年

抗原来源：兔

目录编号：21010

级别：实验级

库存：30

供应商：NewEastbio

标记物：无

克隆性：单克隆

保存条件：-20℃

形态：液体

免疫原：A synthetic peptide from a unique region of Cdc42

规格：100ul

Cdc42 [21010]
[100 µL]

Catalog Number: 21010

Gene Symbol: CDC42

Description: Anti-Cdc42 Rabbit Polyclonal Antibody

Background: Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs).

Immunogen: A synthetic peptide from a unique region of Cdc42

Applications: ELISA, WB, IHC

Recommended Dilutions:
ELISA: 1:100-1:5000
WB: 1:100-1:2000
IHC: 1:50-100

Concentration: 0.2 mg/ml

Host: Rabbit

Format: Liquid

Clonality: Polyclonal

Isotype:

Purity: Purified from serum

Storage buffer:

Preservative: no

Constituents: PBS (without Mg²⁺ and Ca²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Cdc42 antibody recognizes Cdc42 from vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Western blot:

Western blot analysis of Cdc42 proteins. MEF whole-cell lysate was used for western blot with the polyclonal anti-Cdc42 antibody (cat. #21010).

Publications:

1. Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling
PLoS Pathog. 2013 Jan;9(1):e1003142

2. Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
Cytokine. 2012 Jan;57(1):158-68

3. Invadopodia and rolling-type motility are specific features of highly invasive p190bcr-abl leukemic cells
European Journal of Cell Biology Volume 91, Issues 11–12, November–December 2012, Pages 978–987

4. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
J Cell Biol. 2012 Aug 20;198(4):677-93

5. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L32-42

6. The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor beta-Stimulated Aortic Endothelial Cells
Mol Cell Biol. 2011 Nov;31(22):4430-41

7. MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex
PLoS One. 2013 Jul 19;8(7):e70123

8. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
PLoS One. 2013 Sep 3;8(9):e73063

9. The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
J Biol Chem. 2014 Jun 27;289(26):18347-59

10. Cdc42 Inhibitor and Uses Thereof
United States Patent Application 20140194451

11. The α4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
Molecular Pharmacology January 2014 vol. 85 no. 1 50-61

武汉纽斯特生物技术有限公司

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入驻年限：8年

联系人：黄先生

地址：武汉

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