人胎球蛋白A酶联免疫试剂盒

库存 ：100

供应商 ：北京博奥森生物技术有限公司

检测限 ： 8 pg/ml

检测方法 ：ELISA双抗体夹心法

应用 ：ELISA

适应物种 ：Human

标记物 ：HRP

样本 ：cell culture supernates, serum, and plasma.

线性范围：312 - 20,000 pg/ml.Fetuins are blood proteins that are made in the liver and secreted into the bloodstream. They belong to a large group of binding proteins mediating the transport and availability of a wide variety of cargo substances in the bloodstream. The best known representative of these carrier proteins is serum albumin, the most abundant protein in the blood plasma of adult animals. Fetuin is more abundant in fetal blood, hence the name "fetuin" (from Latin, fetus). Fetal calf serum contains more fetuin than albumin, while adult serum contains more albumin than fetuin.

Fetuin-A was originally discovered to be an inhibitor of vascular calcification in early 1990s. Since then the biologic roles attributed to fetuin-A have increased exponentially. Fetuin-A has been demonstrated to play an important role in free fatty acid induced insulin resistance in the liver. Increased fetuin-A in patients with pre-diabetes is associated with increased progression to diabetes and decreased reversal to normoglycemia. Hence fetuin-A is a predictor of adverse glycemic outcomes in pre-diabetes.[unreliable medical source] Increased fetuin-A had been also been linked to increased occurrence of non-alcoholic fatty liver disease and cardiovascular events, believed to be due to its proinflammatory effects. Fetuin-A in contrast has also been demonstrated to have anti-inflammatory properties. It is a negative acute-phase reactant in sepsis and endotoxemia, promotes wound healing, and is neuroprotective in Alzheimer's disease. Decreased fetuin-A is a predictor of increased disease activity in obstructive lung disease, Crohn's disease, and ulcerative colitis. Differential effects on different toll like receptors in different tissues and organ systems may explain these pradoxical effects in different systems.