EPZ5676

保存条件 ：-20°C

保质期 ：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -3090℃ for several months.

英文名 ：EPZ5676

库存 ：详询

供应商 ：详询

CAS号 ：1380288-87-8

规格 ：2mg/5mg/10mg/25mg/50mg/1mL/10mM

ID：T3099

PURITY：0.98

Formula：C30H42N8O3

MolWt：562.71

Appearance：白色粉末

Solubility：G4DMSO：100 mg/mL warmed (177.71 mM)

Bioactivity：EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.

Status：

Pathways：Chromatin/Epigenetic

Target：Histone Methyltransferase inhibitor

Receptor：DOT1L