LY2835219

保存条件 ：-20°C

保质期 ：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2401℃ for several months.

英文名 ：LY2835219

库存 ：详询

供应商 ：详询

CAS号 ：1231929-97-7

规格 ：5mg/10mg/50mg/100mg/1ml/10mM

ID：T2381

PURITY：97%+

Formula：C27H32F2N8

MolWt：506.59

Appearance：白色粉末

Solubility：G4Soluble in DMSO

Bioactivity：Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Status：

Pathways：Cell Cycle/Checkpoint

Target：CDK inhibitor

Receptor：CDK4, CDK6