Crizotinib (PF-02341066)克唑替尼

保存条件 ：-20°C

保质期 ：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1701℃ for several months.

英文名 ：Crizotinib (PF-02341066)

库存 ：详询

供应商 ：详询

CAS号 ：877399-52-5

规格 ：5mg/10mg/50mg/100mg/1ml/10mM

ID：T1661

PURITY：99%+

Formula：C21H22Cl2FN5O

MolWt：450.34

Appearance：白色粉末

Solubility：G4DMSO 9 mg/mL;Water <1 mg/mL

Bioactivity：Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.

Status：USP

Pathways：Tyrosine Kinase/Adaptors

Target：TGF-beta/Smad inhibitor;c-MET inhibitor

Receptor：ALK ;c-MET