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英文名 :Ferrostatin-1 (Fer-1)
CAS号 :347174-05-4
保质期 :1年
保存条件 : -20℃
库存 :900
供应商 :青岛捷世康
规格 : 5mg
基本信息产品名称:Ferrostatin-1 (Fer-1)
- 文名:
- Ferrostatin-1 (Fer-1)
- 别名:
- Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
- CAS号:
- 347174-05-4
- 分子式:
- C15H22N2O2
- 分子量:
- 262.35
- 产品描述: Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity
- 靶点: EC50: 60 nM (Ferroptosis)
- 体内研究: Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction. Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI). Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis
- 参考文献:
1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072. 2. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556. 3. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078. 4. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27. 5. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.
- 溶解性: DMSO : 125 mg/mL (476.46 mM; Need ultrasonic)
- 保存条件: -20℃
合作单位:
中国农业大学、青岛大学、福建茶叶研究所、北京大学、南京农业大学、广州医学院、复旦大学、浙江大学、浙江理工大学等单位。
青岛捷世康生物科技有限公司
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入驻年限:11年